12. Which of the following factor(s) has an actual cap binding activity in translation initiation complex?
(A) eIF2
(B) eIF3
(C) elF4A
(D) eIF4E
(E) elF4G

12. Which of the following factor(s) has an RNA helicase activity in translation initiation complex? (A) eIF1 (B) eIF1A (C) eIF4A (D) eIF4E (E) eIF4G

複選題13. Which of the following factor(s) is a GTP binding protein involved in protein translation? (A) IF-2 (B) IF-3 (C) EF-Tu (D) EF-Ts (E) RF3

14. Quantitative real-time PCR (qPCR) can be used to detect and quantify SARS- CoV-2 virus in different samples. The cycle numbers for the measurement of viral RNA-dependent RNA polymerase (RdRp) expression in sample A and B are 30 and 25, respectively, and those of internal RNAse P control in sample A and B are 28 and 29, respectively. What is the fold-difference of the viral titers between sample A and B? The PCR efficiencies for gene RdRp and RNAse P are closed to 100%, and there is no sampling error. (A) A is 6-folds higher than B. (B) A is 32-folds higher than B. (C) A is 64-folds higher than B. (D) B is 6-folds higher than A (E) B is 64-folds higher than A.

複選題15. Which of the following descriptions are correct for BRCA1? (A) It plays a role in double strand break repair through non-homologous end joining repair. (B) It plays a role in double strand break repair through homology-directed repair. (C) It controls mismatch repair (MMR). (D) Its mutations contribute to microsatellite instability. (E) Its mutations serve as a biomarker for PAPR inhibitors in cancer treatment.

複選題16. Which of the following descriptions are correct for lentiviral vectors and their viral particles in gene therapy? (A) They can infect dividing cells. (B) They cannot infect non-dividing cells. (C) They function by delivering RNA molecules in pair with reverse transcriptase (D) They can integrate their genome into cells. (E) They may cause insertional mutagenesis due to the presence of robust enhancer- promoter sequences.

複選題17. Which of the following is (are) involved in genome editing? (A) Homologous recombination (B) Zinc-finger nucleases (ZFNs) (C) Transcription activator-like effector nuclease (TALENs) (D) Clustered regularly interspaced short palindromic repeats (CRISPR) (E) Histone acetyltransferase (HAT)

複選題18. Which of the following is (are) involved in RNA editing? (A) Watson-Crick base pairing (B) Terminal uridylyltransferase (TUTase) (C) Adenosine deaminases active on RNAs (ADARs) (D) Cytidine deaminases acting on RNA (CDARs) (E) DNA T4 ligase

複選題19. Which ofthe following factor(s) affect post-transcriptional control of gene expression? (A) mRNA stability (B) RNA trans-splicing (C) pre-mRNA cis-splicing (D) mRNA polyadenylation (E) Chromosome remodeling enzymes.

複選題20. Which of the following is (are) involved in RNA splicing? (A) snRNPs (B) ATP (C) RNA polymerase II CTD (D) SR protein (E) Histone acetyltransferase

複選題21. Which of the following is (are) involved in RNA self-splicing? (A) Group I intron (B) Group II intron (C) SR proteins (D) Sm proteins (E) minor spliceosome

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