4. Myasthenia gravis primarily affects women and its defining characteristic is fatigue of unusually rapid onset and severity following the use of certain muscle groups. What symptoms below best allude to the set of muscles affected by this disease?
(A)difficulty walking due to fatigue in the major muscles of the legs
(B)relaxed bladder causing frequent urination
(C) difficulty speaking, difficulty swallowing, and drooping eyelids
(D) difficulty moving the joints of the fingers and toes
(E)difficulty in fine motor control of the fingers, especially the thumb

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