45. 下列哪個神經疾病主要是影響髓鞘?
(A)庫賈氏症(Creutzfeldt-Jakob Disease)
(C)亨丁頓舞蹈症(Huntington's Disease)
(B)巴金森氏症(Parkinson's disease)
(D)威爾森氏症(Wilson's disease)
(E)多發性硬化症(multiple sclerosis)

46. 孩童最常見的眼睛惡性腫瘤是(A)視網膜母細胞瘤(B)脈絡膜黑素瘤 (C)視網膜淋巴瘤(D)視神經膠質瘤(E)眼 皮脂腺癌

47.乾酪性壞死(Caseous necrosis)最常發生於下列哪一種感染?(A)隱球菌(B)念珠菌 (C)結核分枝桿菌(D)單純疱疹病毒(E)金黃色葡萄球菌

48. 下列哪個因素和惡性黑色素瘤的預後最不相關?(A)腫瘤侵犯的深度 (B)腫瘤細胞有絲分裂的數目 (C)腫瘤細胞的大小(D)腫瘤浸潤淋巴細胞的數量 (E)腫瘤上的皮膚溃疡

49.下列有關多囊性卵巢症候群(polycystic ovarian syndrome)的臨床表徵何者有誤?(A)雄性素過多 (B)月經稀少 (C)不孕(D)經痛 (E)肥胖

50.下列何者不是第一型多發性內分泌腫瘤症候群(type I multiple endocrine neoplasia syndrome)好發的腫瘤?(A) parathyroid adenoma (B) pituitary adenoma (C) duodenal gastrinoma (D) pancreas endocrine tumor (E) thyroid medullary carcinom

1. Which of the following statement is NOT correct for the regulation of lactose (lac) operon?(A) lac operon is repressible catabolic operon.(B) lac I repressor binds to operator of lac operon in the presence of glucose.(C) Catabolite gene activator protein (CAP) is a positive control of lac operon without cAMP.(D) 1,6-allolactose functions as a true inducer.(E) I-Z+/i+Z- diploid strain with lacZ inducibility in response to IPTG.

2. Which of the following statement is correct for the development of prophage?(A) Lambda repressor is expressed in the lysogenic bacteria cells.(B) Lambda repressor binds to OR1 to express Cro protein.(C) Lambda repressor binds to Or2 to inhibit the expression of itself.(D) Cro binds to OR1 to inhibit the expression of lambda repressor.(E) Lysogeny is terminated by proteolysis of N protein.

3. Which of the following factor is NOT involved in the efficiency of eukaryotic transcription?(A) Histone modification(B) DNAmethylation on deoxycytidine of CpG island(C) Enhancer and silencer(D) microRNA (miRNA)(E) Deletion of genomic information in B cells

4. Which ofthe following statement is NOT correct for the characteristics of enhancers? (A) Work when located long distances from the promoter. (B) Work when upstream or downstream from the promoter. (C) Work when only one direction is same as TATA box. (D) Work through heterologous promoters. (E) Work by binding one or more proteins.

5. Which ofthe following method is NOT for mRNA quantitation?(A) Southern blot analysis(B) Reverse transcription-quantitative polymerase chain reaction(C) cDNA microarray(D) Transcriptome analysis(E) Next generation sequencing

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