一、為防範嚴重特殊傳染性肺炎（COVID-19）傳播，對於自中華民國境外移 入之人，主管機關於入境時，開立「旅客入境健康聲明暨居家檢疫通知 書」，要求至特定地點檢疫 14 天。請從憲法規定與釋憲實務，說明這項 檢疫措施有無符合憲法。（25 分）
參考法條：
傳染病防治法第 58 條第 1 項：
主管機關對入、出國（境）之人員，得施行下列檢疫或措施，並得徵收 費用：……四、對自感染區入境、接觸或疑似接觸之人員、傳染病或疑 似傳染病病人，採行居家檢疫、集中檢疫、隔離治療或其他必要措 施……。

二、全球處於嚴重特殊傳染性肺炎（COVID-19）疫情肆虐下，各國向國際藥 廠採購疫苗。立法委員為明瞭政府疫苗採購進度及資訊等相關事宜，擬 加以調查。請從憲法與憲法實務，論述立法院之調查權的憲法基礎、行 使方式與限制為何？（25 分）

1. How does light drive the synthesis of ATP ?

2. What is reciprocal regulation of gluconeogenesis and glycolysis ?

3. Please describe the principle of Statins medicines on decreasing serum cholesterol.

1. Please translate the following research abstract into Mandarin.        Cumulative evidence indicates that excessive consumption of calories from saturated fat contributes to the development of Alzheimer's disease (AD). Here, we assess the triggering and progression of AD pathology induced by a high-fat diet (HFD), and the effects of resveratrol, a polyphenol found in common dietary sources with multiple neuroprotective activities. Over 16 weeks, male wild type (WT) and AD transgenic 5XFAD mice were fed a control diet, HFD (60% kcal from fat), or HFD supplemented with 0.1% resveratrol. Resveratrol protected against HFD- induced memory loss in WT mice and prevented memory loss in 5XFAD mice. Resveratrol also reduced the amyloid burden worsen by HFD in 5XFAD, and protected against HFD-induced tau pathology in both WT and 5XFAD strains. At the mechanistic level, resveratrol inhibited the HFD- increased amyloidogenic processing of the amyloid precursor protein in both strains； it also restored abnormal high levels in the proteolytic activity of the ubiquitin-proteasome system induced by HFD, suggesting the presence of a compensatory mechanism to reduce the accumulation of abnormal proteins. Thus, our data suggest that resveratrol can correct the harmful effects of HFD in the brain and may be a potential therapeutic agent against obesity-related disorders and AD pathology.

2. Please draft the title of above-mentioned abstract in English or Mandarin.

1. Please describe three biological processes to contribute proteome complexity from limited genome.

2. Please describe inducible lac operon.

3. Please describe the possible mechanisms that radiation sterilization to be applied in microbial control in food.

V. Please translate the following paragraph into Mandarin. Many enzymes require metal ions for maximal activity. If the enzyme binds the metal very tightly or requires the metal ion to maintain its stable, native state, it is referred to as a metalloenzyme. Enzymes that bind metal ions more weakly, perhaps only during the catalytic cycle, are referred to as metal activated. One role for metals in metal-activated enzymes and metalloenzymes is to act as electrophilic catalysts, stabilizing the increased electron density or negative charge that can develop during reactions.

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