22. Choose a correct statement about eukaryotic RNA polymerases (RNAPS) I, II and III?
(A) Rpb5, Rpb7, Rpb9, Rpb11 and Rpb12 are common subunits for all three RNAPS.
(B) Three loops extending from the clamp of RNAP II--the zipper, lid and rudder--are revealed by crystal structure, and the zipper initiates RNA-DNA hybrid dissociation.
(C) RNAP containing the IIO subunit is involved in the formation of pre-initiation complex, while RNAP with the IIA subunit contributes to transcription elongation.
(D) In RNAP, flexing of the bridge helix is crucial for translocation during transcription, while the trigger loop ensures correct nucleotide selection and positioning.
(E) RNAP II is located in the nucleolus and is highly sensitive to alpha-amanitin, which inhibits RNAP translocation but does not block phosphodiester bond formation.

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