24. Which of the following is NOT classified as an enzyme
(A) ribosome
(B) proteasome
(C) spliceosome
(D) lysosome
(E) ribozyme

25. S-adenosylmethionine is a biological carrier of   (I)  . ATP is a biological carrier of   (II)  . FADH2 is a biological carrier of   (III)  . (A) I: amino group, II: phosphate, III: nicotinamide (B) I: adenosine, II: carboxylate, III: hydrogen atom (C) I: methyl group, II: adenosine, III: electron (D) I: amino group, II: carboxylate, III: hydrogen atom (E) I: methyl group, II: phosphate, III: electron

26. You hypothesize that a newly purified enzyme may function as a serine protease. Which one of the following findings is   NOT   a useful proof of your hypothesis? (A) This enzyme can be inhibited by metal chelator EDTA. (B) A covalent bond between the enzyme and the substrate is transiently formed during catalysis. (C) Structural analysis shows that this enzyme contains the Asp-His-Ser catalytic triad. (D) This enzyme hydrolyzes polypeptides. (E) The catalytic activity of this enzyme is pH-dependent.

27. What following condition of human liver gluconeogenesis will be activated at (A) high concentrations of lipid in blood (B) high concentrations of bilirubin in blood (C) high concentrations of bezoate in blood (D) low concentrations of uroporpyrin in urine (E) low concentrations of glucose in blood.

28. What enzyme in human makes the regeneration of one AMP to ATP need two units of energy released from ATP to ADP? (A) ATP synthetase (B) protein phosphatase (C) pyrophosphatase (D) fructose 2,6-bisphosphatase (E) 6-phosphofructokinase-2.

29. What enzyme catalyzes a non-oxidative reaction? (A) cytochrome P450 (B) complex I (C) glucose 6-phosphate dehydrogenase (D) transaldolase (E) L-gulonolactone oxidase.

30. What type of cells heme catabolism occurs at? (A) liver epithelial cells (B) spleen reticuloendothelial cells (C) bone marrow osteoblasts (D) bone marrow fibroblasts (E) bone marrow granulocyte. (31-34題請參考試卷圖表)

31. Tyrosinemia means (A) High tyrosine concentration in the blood (B) Low tyrosine concentration in the blood (C) High tyrosine concentration in the urine (D) Low tyrosine concentration in the urine (E) None of above

32. Which of the following enzyme defect will cause tyrosinemia I ? (A) Tyrosine aminotransferase (B) Phenylalanine hydroxylase (C) Homogentisate 1,2 deoxygenase (D) Fumarylacetoacetase (E) 3-ketoacyl-CoA transferase

33. Accumulation of which of the following metabolite will cause black urine? (A) α-ketoglutarate (B) Homogentisate (C) Maleylacetoacetate (D) p-hydroxyphenolpyruvate (E) Fumarate

34. Phenolalanine is a ______ amino acid. (A) Ketogenic (B) Glucogenic (C) Ketogenic and glucogenic (D) None of above

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