41. Targeting a protein to proteasome-mediated degradation requires
(A) lipid modification
(B) methylation
(C) acetylation
(D) glycosylation
(E) ubiquitination.

42. Glycosylation of proteins occurs in (A) nucleus and nucleolus (B) lysosome and peroxisome (C) ER and Golgi apparatus (D) mitochondrion, (E) cytosol.

43. Which of the following chemicals could bind G protein-coupled receptor (GPCR)? (A) vitamin D (B) tyrosine (C) TNF-α (D) estradiol (E) carotene

44. Which of the following assays can be optimized for determining hormone concentration in the blood precisely? (A) polymerase chain reaction (B) luciferase assay (C) polyacrylamide gel electrophoresis (D) radioimmunoassay (E) isoelectric focusing

45. Please select one compound that could bind directly to nuclear receptor and regulate gene functions. (A) NAD (B) GTP (C) thyroxine (D) vitamin E (E) selenium

46. Which of the following toxic compounds can inhibit ion channels in human? (A) ouabain (B) saxitoxin (C) cholera toxin (D) botulinum toxin (E) phorbol ester

複選題47. Which one is correct for the following descriptions about RNA polymerase (Pol). (A) RNA Pol I and III found and function in nucleoplasm (B) rRNA mainly synthesis by RNA Pol I in the nucleoplasm (C) U6 snRNA and 5.8S RNA synthesized by RNA Pol III (D) snRNAs are synthesized by RNA Pol II (E) 7 SL RNA is synthesized by RNA Pol III involved in protein synthesis in the nucleoplasm

48. Which glycosaminoglycan is free of protein core (A) Chondroitin sulfate (B) Dermatan sulfate (C) Hyaluronic acid (D) Heparan sulfate (E) Keratin sulfate

49. Integrin can bind to which peptide below? (A) AKAEKAA (B) AKGEAAA (C) AKADGAA (D) ARGDSAA (E) ARGESAA

複選題50. Mitosis and meiosis accomplish segregation of the replicated DNA to two or more daughter cells. Which of the following is characteristic of both mitosis and meiosis? (A) correct centrosomal duplication is required (B) The resulting cells are diploid (2n). (C) The resulting cells are haploid (1n). (D) Spindle fibers attach to chromosomes at their kinetochores. Chiasmata form between chromosome arms. (E) All of above are not correct

1. What functional groups are present on this molecule? (A) Hydroxyl and ketone (B) Hydroxyl and aldehyde (C) Hydroxyl and carboxylic acid (D) Hydroxyl and ester (E) Ether and aldehyde

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